HekeTiss presented mechanistic insights into the activation of adipose-derived stromal cells (ASCs), highlighting a novel RGD/integrin-mediated pathway that enhances their regenerative potential in ischemic environments.

Poster presentation

Title: A Novel RGD/Integrin-Induced Regulation to Switch Adipose-Derived Stromal Cells to a Highly Regenerative State: Mechanism and Application to Ischemic Wound Treatment

Authors: Nicolo Brembilla, Ali Modarressi, Dominik André-Lévigne, Estelle Brioudes, Florian Lanza, Hubert Vuagnat, Stéphane Durual, Laurine Marger, Wolf-Henning Boehncke, Karl-Heinz Krause, Olivier Preynat-Seauve

This work describes a novel mechanism by which RGD-mediated integrin signaling induces a pro-regenerative state in adipose-derived stromal cells, supporting their use in therapeutic strategies aimed at restoring vascularization and healing in ischemic chronic wounds.